Now in beta. Looking for collaborators. Guardians of the Genome is a serious game designed to teach players (students and the public) about accurate DNA structure through self-guided, hands-on experiences. Equipped with tools emulating enzymes involved in DNA mismatch repair, players are tasked to repair base-pairing errors along a strand of DNA in a virtual nucleus. Mastery of the game solidifies an understanding of complementary base pairing, differentiating the four nitrogenous bases and identifying the enzymes and processes involved in DNA mismatch repair — a fundamental process occurring regularly within all the cells of our bodies.